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Two Randomized Trials of Linaclotide for Chronic Constipation

The extracellular matrix components are degraded by macrophage-derived matrix metalloproteinases, (201-203) elastases, and cathepsins (Figure 5) (204)

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ALCAR for Depression Depends on What Kind of Depression Although 10 double-blind, randomized, placebo-controlled (DBRPC) studies of ALCAR for depression have been done, those showing significant benefits were mainly in elderly patients, patients with dysthymia (chronic mild-to-moderate depression), and those with medical conditions such as fibromyalgia or cancer (Wang et al