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[124] We sought input on the following questions: What non-claims-based indicators could be used to improve payment accuracy and reduce health disparities, and how can CMS ensure that they are collected uniformly and documented consistently without unduly increasing administrative burden

Glutathione is a naturally-produced antioxidant made in the liver

By altering lipid mediator profiles, dampening cytokine cascades, and enhancing cellular resilience, omega-3 supplementation has shown potential to attenuate systemic inflammation and improve clinical outcomes in septic patients (Okut et al., 2025)

Defective IL-12 production was also observed during Mycobacterium tuberculosis infection, in which diabetes is likewise known to be a strong risk factor

These pathways include the metabolisms of urea cycle, glycine and serine, arginine and proline, methionine, aspartate, betaine, ammonia recycling, alanine, spermidine and spermine biosynthesis, tryptophan, purine, glutamate and methylhistidine (Figures 5A,B)