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The proposed condensation domain C* (CesA_C2) 8 transfers the hydroxy group of D- O -Leu-D-Ala- S -PCP to the thioester carbon of L- O -Val-L-Val- S -PCP to form an ester bond resulting in the PCP-bound tetradepsipeptide L- O -Val-L-Val-D- O -Leu-D-Ala- S -PCP ( DP4 ) 24 , which is subsequently transferred to the serine hydroxy group of the CesB C-terminal TE domain (Fig

The genomic features overlapping with the features were identified using the DMAP inbuilt Geneloc function and then with GenomicRanges with promoter overlaps (sourced from TxDb hg19 genomic data)

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Cycled Protocol Design Epithalon is typically dosed in cycled protocols (often 10-20 day cycles 1-2 times per year), supporting flexible integration with other longevity protocols