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Talk with your doctor or a registered dietitian about whether or not you should supplement with B12 and how much you should take.

And anyone with lymphedema affecting the legs should avoid thigh injections on the affected side

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In the latter study, the researchers hypothesized that vitamin B12 may activate an inflammatory process in bacteria that normally lives on the skin, but which can promote acne when inflamed, according to Live Science

Nevertheless, focusing exclusively on a NE threshold for AVP initiation may have shortcomings, as it appears plausible that other patient-dependent factors may also play a role [15]