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Some human trials suggest oral glutathione at 250500 mg/day may reduce melanin production in sun-exposed areas and lighten dark spots, though results are moderate and vary by individual

Alpha Arbutin:Naturally occurring antioxidant and skin brightenerwhich reduces hyperpigmentation and dark spots

400 g of folic acid, 6 g of vitamin B12, and 3 g of betaine References 1

doi: 10.1152/physrev.00008.2013

By neutralizing free radicals and preventing oxidative stress, glutathione supports cellular health and may reduce the risk of chronic diseases such as cancer, heart disease, and neurodegenerative disorders