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Loss of the wild-type allele of either of these two genes is frequently observed in familial breast and ovarian cancers [19] and BRCA1/2 -deficient ovarian cancer patients have generally better responses to platinum and are associated with better clinical outcome [20]

10.1186/s41065-024-00328-w Hereditas

Further studies revealed that the activation of these genes may be caused by the acidic microenvironment of the tumor cells, suggesting that the bacteria are capable of responding positively to the acidic TME

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Topical absorption is significantly lower than injection