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These changes cause mitochondrial injury, granular degeneration, and vacuolar degeneration of renal tubular epithelial cells (125), leading to proximal tubular necrosis, renal fibrosis (126), persistent albuminuria, reduced glomerular filtration rate, and elevated blood pressure (127)

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Chronic alcohol use damages hepatocytes and reduces phase II conjugation capacity

This multifunctional peptide also shows a potent anti-collagenase effect, preventing enzymatic degradation of collagen fibers

Consistent with PTS being essential for growth in the macrophage cytosol, ptsH mutants were unable to replicate in BMDM alone or when combined with hexose phosphate and glycerol ( glpD/golD/uhpT / ptsH ) mutants (Fig 6A)