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PD A key pathological feature of PD is the loss of dopaminergic (DA) neurons in substantia nigra (Lpez et al., 2019)

10.3390/biomedicines13061458 193 SpergelJ

At present, 1-AR merely represents a potential therapeutic target confined to the realm of basic research, and further translational validation is indispensable to corroborate its relevance for clinical application 18,100

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Some studies suggest reduced NET formation in neutrophils from older individuals [164, 165], while other ones indicate an increase in NET production with age [166]