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The first study ex vivo in Ussing chambers (1999) evaluating the epithelial barrier function in colonic tissue from UC patients with mild or moderate macroscopic disease activity showed a 50% decrease of the total electrical wall resistance (assessed by transmural impedance analysis) when compared to healthy subjects

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In contrast, our approach breaks a single infusion into multiple NAD shots across days or weeks

There is, however no apparent correlation between ROS production and the reduction potentials as e.g

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