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Hopkins , C

Repeated injections in one spot cause scar tissue buildup and reduce absorption over time

The activation of TLR3 in these cells induces the stimulation of TRPML1, which, in turn, by inducing the release of lysosomal Ca 2+ into the extracellular environment, can promote the fusion of the plasma membrane with the lysosomal membrane and increase the release of ATP from the organelle (Beckel et al., 2018)

Its also supposed to increase production of lipids, which can also help with moisturisation

The studies documenting hair-relevant effects DPC proliferation, follicle elongation, stem cell recovery used direct tissue contact, which topical application most closely replicates