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Significant hepatotoxicity with azathioprine has not been reported in any major adult and pediatric studies

We purified and identified several compounds for their ability to promote an efficacious neurotrophic effect on cultured hippocampal neurons fully capable of replacing foetal calf serum, critically involved in hippocampal neuron survival in culture

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It further suggests the possibility that the inhibition of beta-oxidation might result from an initial accumulation of H 2 O 2 , which subsequently exits the cell, initiating the development of UC