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Results: DDC mice had increased AST, ALT, bilirubin, bile acids, ductular reaction and macrophage infiltration and reduced hepatocyte mRNA expression of Abcb11, Abcg8, Nr0b2 (SHP), Nr5a2 and Abcc2 mRNA relative to chow fed mice

Although little is known about the pathophysiology of PTSD + AUD, PTSD and AUD have each been associated with marked dysfunction in brain glutamate (i.e., excitatory) and Gamma-Aminobutyric Acid (GABA) (i.e., inhibitory) systems, making these systems promising targets for pharmacological intervention

doi: 10.3389/fnins.2025.1515374 Received 22 October 2024 Accepted 03 February 2025 Published 20 February 2025 Volume 19 - 2025 Edited by Matilde Otero-Losada, National Scientific and Technical Research Council (CONICET), Argentina Reviewed by Michael Henderson, Van Andel Institute, United States Minyoung Oh, Asan Medical Center, Republic of Korea Lenora Higginbotham, Emory University, United States Updates Copyright 2025 Rosal, Martin and Strafella

While GHK Cu shows promising effects related to gene expression patterns connected to aging biology, it is not a substitute for foundational longevity practices such as proper nutrition, sleep, inflammation management, and metabolic health

Oxidative stress, energy metabolism disorders, and inflammatory responses that occur during this process cause severe damage to myocardial cells