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Humane endpoints: Animals were euthanized if tumor volume exceeded 2000 mm, if tumors reached 10% of body weight, if body weight loss exceeded 2025%, or if signs of cachexia or severe distress were observed

Lei, Jiaojiao

Plant PRRs comprise receptorlike kinases (RLKs) and receptorlike proteins (RLPs) 4 , which induce downstream immune responses including reactive oxygen species (ROS) bursts, calcium ion (Ca 2+ ) influx, mitogenactivated protein kinase (MAPK) cascades, and defense gene activation 5,6

(2019) performed a randomized controlled trial involving 56 women with PCOS, revealing a decrease in hirsutism, total testosterone, hs-CRP, and MDA, alongside an increase in TAC and total GSH among participants administered 5 g of melatonin twice daily for 12 weeks, in contrast to the placebo group [186]

Leukocytes may release oxidants during phagocytosis that cause oxidative stress to the erythrocytes