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the CDR3 region of the antigen binding molecule-encoding nucleic acid sequence is changed or "evolved. the invention provides an array (e.g., biochip) comprising a plurality of polypeptides, wherein each polypeptide is immobilized to a discrete and known spot on a substrate surface to form an array of polypeptides, wherein the plurality of polypeptides comprise a sample of (i.e., a subset of), or all of, the antigen binding sites that are isolated from and/or expressed by an individual, or, complementary to antigen binding sites isolated from and/or expressed by the individual

However, in M.tb -infected immunocompromised mice, JHU083 showed reduced therapeutic efficacy [36]

Thus, single nucleotide polymorphisms (SNPs) in glutathione-related genes might modulate the negative impact of this metal on the kidneys

34 They are found in body fluids such as saliva, urine, semen, milk, and blood

Data availability Data supporting the main conclusions of this study are included in the manuscript