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Repeated prior withdrawal episodes may also sensitise the nervous system, making each successive withdrawal more difficult

These findings support combined strategies that integrate standard therapies with drugs targeting mechanisms associated with DTP cells, as summarized in Table 4 , and underscore the importance of early intervention approaches to reduce the reservoir of cells capable of triggering a relapse

Indeed, data addressing the full spectrum of cross-kingdom interactions remain very limited in the field of skin oncology

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The peak observed at around 1313 cm 1 corresponds to the stretching vibration of the C-N bond, while the peak at 2911 cm 1 is assigned to the C-H band [24]