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Despite the success of glucagon-like peptide-1 receptor agonists (GLP-1RAs), many patients fail to achieve or sustain sufficient weight reduction with current therapies

Dual inhibition of SGLT2 and DPP-4 highly promotes a distal tubular sodium delivery and thereby contributes to the appropriate modulation of preglomerular arteriolar tone and intraglomerular pressure via an increase in adenosine release and a reduction in PGE2 secretion from macula densa during DKD (150)

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