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Lv et al., 2018

J Psychopharmacol

Reactive oxygen species: metabolism, oxidative stress, and signal transduction

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

We compared iPSCs and iNs_D14 incubated with labeled glucose for 5, 15, 60, or 360 min and analyzed labeling of glycolytic metabolites, as well as metabolites from downstream pathways such as the tricarboxylic acid (TCA) cycle or the pentose phosphate pathway (PPP) (Fig