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The kidney is considered to be the main source for the GPx3 in plasma, which is primarily synthesized in the kidney proximal tubular cells 2,3

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150 mg/L AFB 1 (diluted in dimethyl sulfoxide), 2 mmol/L NADPH, 5 mmol/L GSH, rat cytosol, and recombinant GSTA2X (2.5 g total protein) were added at the same time

A., Solyom, L., Enesco, H., and Ledwidge, B

To be clinically translation, our group has developed a new structure small molecular drug candidate, named IMA-1, which significantly blocked NASH progression in both mice and monkeys with high safety