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The molecular weight is 1419.55 g/mol with a calculated isoelectric point of approximately 3.64.0 , rendering it an acidic peptide that carries a net negative charge of approximately -2 at physiological pH

Such metabolic disorders can initiate a cascade of events, including the dysregulation of the tricarboxylic acid cycle (TCA), which is integral to the oxidative phosphorylation processes in cardiac myocytes (6)

The peptide according to item 434, wherein said uncommon amino acid is glycosylserine 657

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Notably, a recent study demonstrated that Ganoderic acid D overcomes gemcitabine resistance by promoting the degradation of HIF-1 driven by MDM2, which leads to a reduction in glycolysis in triple-negative breast cancer cells (Luo et al., 2024)