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The systemic inflammatory response generated by the production of cytokines and chemokines during intestinal I/R injury might profoundly disrupt the bloodbrain barrier (BBB) (Guo et al., 2025)

El Sahly says that it only happens in a small fraction of people

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Notably, currently available therapies for RA, such as cytokine (TNF and IL-6) blockers or inhibitors of the JAK-STAT pathway 43 , exclusively tackle the inflammatory phase of the disease but do not interfere with the underlying processes that initiate the onset of arthritis and therefore often need to be given life-long 44