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545 CD40 activation can induce FAO and glutamine metabolism in macrophages, promoting M1 polarization to enhance anti-tumor activity, which provides a side effect of anti-CD40 treatments in cancer

Accordingly, OS in MS should be regarded not merely as a secondary byproduct of inflammation, but also as an active driver of demyelination, axonal injury, and lesion evolution

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Typically, patients transit to mild cognitive impairment (MCI) around 6-10 years later, with approximately 15% progressing to AD within 2 years and one-third within 5 years

It is especially effective against free radicals in the eye