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Dogs with idiopathic IBD also have up-regulated activity of the JAK/STAT pathway marked by phosphorylated STAT3 (pSTAT3) overexpression (141)

The SigR-RsrA system of Streptomyces coelicolor and the Spx systems of Bacillus subtilis and Staphylococcus aureus have been most closely studied (Kang et al., 1999

However, the pleiotropic characteristic of cytokines and the widespread presence of cytokine receptors in various tissues lead to systemic toxicity if cytokines are delivered systemically, so in situ delivery of cytokines to tumors is necessary