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5 Here we summarized the complex mechanisms of GLP-1RAs and their latest advancements in treating various diseases, such as musculoskeletal inflammation, obesity, cardiovascular diseases, NAFLD, neurodegenerative diseases, and various cancers

These may impair methylation and cerebral folate transport, with therapeutic implications for folinic acid supplementation

Clinical data from the STEP 1 trial shows average weight loss of approximately 5.9 percent of baseline body weight at 12 weeks

Continued research efforts are expected to lead to broader adoption of metformin in clinical practice

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