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Repression of transcription by the glucocorticoid receptor: A parsimonious model for the genomics era

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p53 combines with the promoter region of SREBP-1, which is a transcription factor that regulates various genes involved in lipid metabolism, leading to the inhibition of SREBP-1 expression

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However, Hcy-mediated increased lipid peroxidation and reduced free radicals cause inflammation and acute endothelial abnormalities, hastening the atherosclerotic process that results in cardiovascular disease