glutathione sepharose regeneration Schematic diagram showing the conversion of (GSH) from the linked agarose In-house preparation of hydrogels for – optimized to yield up to 1mg of soluble GST tagged protein gst glutathione interaction Glutathione in

doi: 10.1016/j.bcp.2017.02.009 40 ChalmersJDBurgelP-RDaleyCLDe SoyzaAHaworthCSMaugerDet al

Howerton CL, Bale TL

The most primary and urgent aspect is to provide authoritative definitions and interpretations of doseresponse models for hormesis from a toxicological perspective

doi: 10.1016/0300-483x(91)90004-k

The nonenzymatic functions of GSTs involve their interactions with cellular proteins, such as, Jun N-terminal kinase,(JNK), tumor necrosis factor receptor-associated factor-2 (TRAF2), apoptosis-signal-regulating kinase 1 (ASK), serine/threonine kinases (PKA, PKC), and tissue transglutaminase 2 (TGM2), during which, either the interacting protein partner undergoes functional alteration or the GST protein itself is post-translationally modified and/or functionally altered [53], [74]