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Caspase-9 is activated in a cytochrome C-independent manner early during tnf-induced apoptosis in murine cells

63,64 Ultimately, through regulation at the tissue and organ levels, these processes influence the onset and progression of diseases in the organism

To identify which pathway contributes most to QEC tolerance to Cys-Cys limitation, we treated QECs with specific inhibitors targeting STAT3 and NRF2 activity: AG-490 [40] and ML385 [41], respectively