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FIGURE 4 8.1 Iron metabolism dysregulation Iron is unevenly distributed in the cerebral cortex: the metal burden in motor-related nucleiincluding the basal ganglia, amygdala, substantia nigra, hippocampus, and red nucleusis significantly higher than in other neural regions (Bartzokis et al., 2007)

The data indicated that ES-induced cell death did not involve either the cleavage or activation of caspase 3 activity, known as a hallmark of apoptosis

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Subsequently, DHICA undergoes conversion into the corresponding quinone species 53

denticola cultures (containing 7.5 10 6 spirochete cells) were first mixed with 25 l of either normal human serum (NHS) or heat-inactivated serum (HIS, 56 C for 30 min) and then incubated at 37 C in the anaerobic chamber for 90 min