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Environmental Health Perspectives 130, 117007

Pathogenesis of NASH: the impact of multiple pathways

10.1021/acsbiomaterials.0c00878 107 SuZ.BurchfieldJ

Most importantly, targeting either GSH with the inhibitor BSO or Nrf2 through an siRNA approach or with the small molecule inhibitor ML385 sensitised resistant MRT cells to cisplatin-induced cell death suggesting that targeting the Nrf2/GSH antioxidant defence pathway may present a novel therapeutic avenue in the design of new treatment strategies for MRT and a means of overcoming chemoresistance