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Theoretically, phellodendron might also inhibit CYP2D6

Le Henaff C, Mansouri R, Modrowski D et al (2015) Increased NF-B activity and decreased Wnt/-catenin signaling mediate reduced osteoblast differentiation and function in F508 cystic fibrosis transmembrane conductance regulator (CFTR) mice

Mar 2021;36(2):e2767

An adequate evaluation of the glutamine hypothesis would be to supply patients with hypoglutaminemia at ICU admission with a dose of glutamine that normalizes plasma glutamine together with an adequate caloric and protein supply, not less than 50 % of energy expenditure and not less than 50 % of ESPEN-recommended protein supply

Mice were treated for 12 weeks before being sacrificed