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These findings provided direct support for our hypothesis that the microenvironment-triggered disintegration of cPLT-protein complexes into small sized protein units could facilitate the penetration of protein nanodrugs in the plaque stroma

Echinatin significantly promotes the expression of glutamate cysteine ligase, maintaining the balance of GSH metabolism

It is important to note that this mechanism, while biologically plausible, is not yet validated by large-scale controlled trials, and individual results vary considerably depending on baseline melanin levels, skin type, and dosage

Topical retinoids continue to be the gold standard

However, their effect may be particularly dose-dependent and more research is needed before specific recommendations can be made