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Front Pharmacol 10:1295 Chung HY, Kim DH, Lee EK, Chung KW, Chung S, Lee B, Yu BP (2019) Redefining chronic inflammation in aging and age-related diseases: proposal of the senoinflammation concept

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Reports also show that intravenous administration of PACAP-38 can elicit a migraine-like attack in patients (Schytz et al., 2009) and cause sustained meningeal vasodilation and migraine-like photophobia in mice (Markovics et al., 2012)

When patients with JakobCreutzfeldt disease underwent PET imaging with [ 11 C] d-l-deprenyl and [ 18 F]fluorodeoxyglucose ([ 18 F]FDG), increased astrogliosis and decreased cerebral glucose metabolism were observed in the frontal, occipital and parietal cortices and cerebellum 351,352

However, analysis of mutants in the OASTL revealed that the Cys synthesis can be restricted to a single compartment without affecting survival and with only small effects on growth (Watanabe et al., 2008