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Significantly elevated homocysteine has been observed in people suffering with cardiovascular disease, stroke, neurodegeneration (Nelson et al, 2016) and frailty in old age (Guaita et al, 2021) and elevated homocysteine is associated with a reduced blood flow to the small vessels in the brain (reduced microcirculation) (Hassan et al, 2004) which is an important connection because a reduced microcirculation may increase the risk of developing Alzheimers disease, amyotrophic lateral sclerosis (ALS) or Parkinsons disease (Erdener and Dalkara, 2019)

10.1371/journal.pone.0016883 79 SharpleyC

However, it revealed no statistically significant difference in the change in UPDRS total score between the hydrogen water group and the placebo group at 72 weeks (Yoritaka et al., 2016)

M.FactorS

For men, this means five drinks or more in the same time period