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Roles of pyruvate, NADH, and mitochondrial complex I in redox balance and imbalance in cell function and dysfunction

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Proteostasis in cardiovascular health and disease Cardiovascular tissues, particularly the heart, operate under constant mechanical, metabolic and oxidative stress and therefore depend critically on robust proteostasis to sustain contractile function, bioenergetic efficiency and cellular survival

In addition, other genes in the pyruvate dehydrogenase complex , such as PDHB or DLD, can cause pyruvate dehydrogenase deficiency

Plant J 41:1530 Wali M, Gunse B, Llugany M et al (2016) High salinity helps the halophyte Sesuvium portulacastrum in defense against Cd toxicity by maintaining redox balance and photosynthesis