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Compared to other microtubule inhibitors, Noscapine selective nature allows for less toxicity and no peripheral neuropathy, hypothesized to arise from dysfunctional cell cycle checkpoint mechanisms in tumor cells that make them more vulnerable to mitotic slippage and cell death upon exposure (168, 169)

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In line with this, a study in rotating shift workers from the automotive industry found that NSW significantly reduced plasma concentrations of multiple immune markers, including pro- and anti-inflammatory cytokines (TNF-, IL-2R, IL-1RA, IL-4, IL-12, IL-17), chemokines (IP-10, MIP-1, MIP-1, RANTES), and growth factors (EGF, FGF, VEGF), indicating a broad suppression of immune pathways linked to circadian disruption and higher susceptibility to infection and cancer 113

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