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The main organ involved in primary creatine deficiency is the brain, and 1H-MRS may show a significant reduction or absence of the creatine peak

[] D-amphetamine is used to promote brain oxidative stress in a rat model of mania

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High concentrations of melatonin are pro-oxidant in cancer cells, but do not increase ROS production in lymphocytes (Radogna et al., 2009)