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This sustained exposure is primarily driven by congestion within the meningeal lymphatic system (47)

Introduction Beta-amyloid peptide (A), and mutations that lead to its accelerated oligomerization are the key to the onset of Alzheimers disease (AD), one of the most common neurodegenerative diseases ( A is produced from beta-amyloid precursor protein (APP) by -site APP-cleaving enzyme 1 (BACE1) and gamma-secretase ( A is secreted pre- and postsynaptically ( A accumulation has been shown in the aging brain ( in vitro and in vivo

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