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*Correspondence: Shuyu Zhang, [email protected] These authors have contributed equally to this work This article was submitted to Molecular and Cellular Oncology, a section of the journal Frontiers in Oncology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

MOTS-c's AMPK activation increases NAD+-dependent processes immediately, but 5-Amino-1MQ's NNMT inhibition takes 90120 minutes to elevate intracellular NAD+ meaningfully

ClinicalTrials.gov(NCT02500017)

The numbers from clinical trials tell the story clearly

It's a live and learn process alright