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We demonstrated increased levels of the glutamate N-methyl-D-aspartate receptor (NMDAR) co-agonist D-serine and its precursor L-serine in the (1) rostral putamen of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys 3 , (2) post-mortem striatum of human PD brains, and (3) CSF of de novo PD patients compared to patients with other neurodegenerative diseases and controls 4