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Epitalon has been shown to significantly increase the expression of key antioxidant enzymes: Superoxide dismutase (SOD-1) Catalase NAD(P)H quinone dehydrogenase 1 (NQO1) These effects are mediated via the Keap1/Nrf2 signaling pathway [40, 41]: a master regulator of cellular redox balance

Aspartame is metabolized by gut esterases and peptidases to three common chemicals: the amino acids, aspartic acid and phenylalanine, and small amounts of methanol

Prooxidants, such as O 2 and Asc, could re-reduce Fe 3+ (Cu 2+ ) to Fe 2+ (Cu 1+ ) and restore these ions in the game (Salehi et al., 2020)

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