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Cell culture studies In laboratory studies using 3T3-L1 adipocytes, a commonly used fat cell line, researchers found that 5-amino-1mq significantly reduced intracellular levels of 1-methylnicotinamide, confirming that it was successfully inhibiting NNMT

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Initially, the production of cyclic-di-GMP, confirmed by LC-MS, was found to increase upon illumination when compared to the apo (i.e., no chromophore bound) and AdoCbl-bound dark states of the protein (Fig