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Risk of ERD for SARS-CoV-2 vaccines Safety concerns for SARS-CoV-2 vaccines were initially fuelled by mouse studies that showed enhanced immunopathology, or ERD, in animals vaccinated with SARS-CoV following viral challenge 55,56,57,58

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Cognitive improvement studies in aged mice demonstrated significantly faster escape hole finding in maze tests, evidence of decreased brain inflammation, and increased histone deacetylase 2 labeling indicating epigenetic pathway activation