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The abnormal release of Ca 2+ from the mitochondria to the cytosol leads to the activation of microglia, neuroinflammation, and finally, cell death [29, 93]

509 The combination of suberosin and thiazolidinedione reduces serum iron concentration, decreases MDA levels, and downregulates the expression of ACSL4, LPCAT3 and LOX in the heart tissue of diabetic rats

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Model building and refinement To obtain the atomic models for MARV and EBOV polymerase complexes, the cryo-EM maps at atomic or near-atomic resolutions were used for automated and de novo model building by ModelAngelo 58