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2 Biochemistry and the metabolism of D-lactate In mammals, D-lactate is produced through the breakdown of carbohydrates and lipids during the generation of methylglyoxal (MG) (Figure 1)

Normally TCAC reactions produce 3 NADH and 1 FADH 2 , resulting in a 3:1 NADH to FADH 2 ratio (Figure 6a)

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23 Ergothioneine accumulates intercellularly, inside the mitochondria and nuclei to provide protection against oxidative damage in DNA

Additionally, the device was coated with appropriate presynaptic adhesion molecules to reconstruct the synaptic environment, thereby forming an appropriate synthetic synapse