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The need for biomarkers in the ALS-FTD spectrum: a clinical point of view on the role of proteomics

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The progressive depletion of vitamin E in the circulatory system, accompanied by an increase in plasma isoprostanes and prostaglandins, disrupts the oxidant-antioxidant balance, potentially impacting survivability during the experimental porcine septicemia (Basu and Eriksson, 2000b)

Zinc deficiency also decreases the production of Th1 cytokines (TNF-, IL-2, and IFN-), whereas the Th2 cytokine response (IL-10, IL-6, and IL-4) is less affected