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The FDA approved naloxone in 1971 as a prescription-only medication for intravenous, intramuscular, and subcutaneous administration to reverse postoperative respiratory depression induced by opioid analgesics

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The success with GLP-1 drugs has also prompted researchers to start investigating in detail the physiology of GLP-1 in the gut and the brain

In the following narrative, we summarize the compounds that have become more popular in HCC therapy in the last few years, which are able to inhibit HCC cells in different pathways from ferroptosis, and may play a great role in the future of hepatocellular carcinoma therapy ( Table 1 )

NMR experiments were recorded on Agilent DD2 400 MHz spectrometers at ambient temperature