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Summary: Long-term calorie restriction doesnt appear to directly impact IGF-1 levels in humans, although it may make it less active

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Glutathione is sometimes referred to as the "master antioxidant" in the body, with a protective role in the liver, a hardworking organ that needs particular protection from oxidative stress

Notably, primary bile acid biosynthesis was exclusively enriched at the early phase, suggesting a rapid development of bile acid production function in iHLOs at this stage