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IV and short-duration oral trials METAOD001-004 enrolled smaller groups of healthy or obese men with single doses or 1-week dosing across IV (25-400 mcg/kg) and oral (9-54 mg) routes

Melatonin ameliorates anxiety-like behaviors induced by sleep deprivation in mice: role of oxidative stress, neuroinflammation, autophagy and apoptosis

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Fewer systemic side-effects compared to hGH Because AOD 9604 does not significantly elevate IGF-1 or impair glucose/insulin regulation (in trials), it may carry lower risk of some growth hormone-associated adverse effects

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