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Similar content being viewed by others Introduction As advances in cancer therapies have improved patient survival, there are growing concerns about the long-term side effects of cancer therapy, and chemotherapy-induced peripheral neuropathy (CIPN) can persist for months or even years after the completion of treatment [1]

Interventions targeting this axisincluding GLP-1RAs/SGLT-2is, microbiota-directed therapy, and anti-IL-6/NLRP3 agentshold significant promise (Figure 6)

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SPPS was chosen as the synthetic method as it can produce a large variety of modified peptides for screening by changing the building blocks (Fmoc-AA-OH) used

[DOI] [PubMed] [Google Scholar] 42.Fujioka K., Casida J.E