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Graphical Abstract 1 Introduction Amyotrophic lateral sclerosis (ALS) is a fatal disorder characterized by the selective degeneration of upper motor neurons in the primary motor cortex and lower motor neurons in the brainstem and spinal cord, leading to progressive muscle weakness and atrophy (Masrori and Van Damme, 2020)

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Indeed, flow cytometric evaluation of resting B6 MZB confirmed increased phosphorylation of both mTOR and its canonical target S6 (Fig

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