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10.1038/s41467-022-33323-8 224 WangF.MinJ

Rana I, Khan N, Ansari M et al (2020) Solid lipid nanoparticles-mediated enhanced antidepressant activity of Duloxetine in lipopolysaccharide-induced depressive model

However, when administered at much lower doses, LDN exhibits unique properties that can modulate the immune system, reduce inflammation, and increase the body's production of endorphins